Proven solution - findings of clinical research studies

Revitive Aerosure is a drug-free, Class 1 respiratory device that has been shown to reduce breathlessness. Below are some of the research studies that have been carried out with both Revitive Aerosure and the technology Revitive Aerosure uses (IMT).

Improving inspiratory muscle strength in COPD using IMT

A controlled study analysed the effects of IMT on exercise capacity, dyspnea, and inspiratory fraction during exercise in patients with COPD. Daily inspiratory muscle strength and endurance training were performed for 8 weeks in patients with COPD. Results showed an increase in muscle strength following IMT, as well as an increase in inspiratory fraction, suggesting a reduction in dynamic hyperinflation. Other findings were improved breathing pattern and decreased perception of dyspnea. These outcomes were not achieved in the control group.

Petrovic, M., Reiter, M., Zipko, H., Pohl, W., & Wanke, T. (2012). Effects of inspiratory muscle training on dynamic hyperinflation in patients with COPD. Int J Chron Obstruct Pulmon Dis, 7, 797-805.

In another study, COPD patients were randomised into a group that received IMT for one year, or a control group that received IMT training but with a very low load. Results showed a statistically significant increase in inspiratory muscle strength, 6-minute walk distance, Borg score and health-related quality of life scores in the IMT group but not in the control group.
The changes were maintained at the end of the year.

Beckerman, M., Magadle, R., Weiner, M., & Weiner, P. (2005). The effects of 1 year of specific inspiratory muscle training in patients with COPD. CHEST Journal, 128(5), 3177-3182.

The aim of a further study was to determine the relative value of different tests in detecting changes in inspiratory muscle endurance following inspiratory muscle training in COPD. Subjects were randomised to either IMT or sham IMT training three times per week for 8 weeks. Changes in inspiratory muscle endurance observed in the IMT group were greater than baseline and also compared to the sham IMT group.

Hill, K., Jenkins, S. C., Philippe, D. L., Shepherd, K. L., Hillman, D. R., & Eastwood, P. R. (2007). Comparison of incremental and constant load tests of inspiratory muscle endurance in COPD. European Respiratory Journal, 30(3), 479-486.

Improving inspiratory muscle strength in healthy subjects using IMT

This study investigated whether breathing against a vibration stimulus would elicit increments of spontaneous and maximal inspiratory mouth pressure and tidal mean inspiratory flow upon stimulus removal. Healthy subjects performed 3 maximal inspirations before and after 10 inspirations against a resistive vibration-type load stimulus, a resistive breathing stimulus and a control with no load, in a random order. Only the resistive vibration-type stimulus increased tidal and maximum mouth pressure. Mean inspiratory flow also increased with the resistive vibration-type stimulus.

Sumners, D. P., Green, D. A., Mileva, K. N., & Bowtell, J. L. (2008). Increases in inspiratory neural drive in response to rapid oscillating airflow braking forces (vibration). Respiratory physiology & neurobiology, 160(3), 350-352.

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